Background :
@EN Although treatment with etretinate or modified Ingram method is effective for psoriasis, both regimens have limitations because of the risk of long-term toxicity.
@ES Objective :
@EN We performed retinoid-modified Ingram combination therapy expecting greater therapeutic efficacy and less side effect.
@ES Methods :
@EN Thirty three plaque-form psoriasis patients were included. Pretreatment with etretinate for 1. to 2 weeks was followed by modified Ingram therapy in combination with etre4tinate.
@ES Results :
@EN 1. Among 33 patients, clearing was shown in 26 patients(78.8%), 4 patients (1.21%) was improved, and 3 patients(9.1%) showed failure. The numbor of cleared patients was 13/15 (86.7%) in moderate group, and 13/18 (72.2%) in severe group.
2. In cleared patients, the mean numbers, duration, and total dose of UVB therapy reaching grade 4 were 11.9, 24.5 days, 1348.5 mJ/cm2 in trunk, and 13.5, 29.1 days, 1733.3 mJ/cm2 in extremities. Their differences between trunk and extremities
were
not
statistically significant (p>0.05).
3. Incleared patients, the mean numbers, duration, total dose of phototherapy, and total dose of etretinate reaching grade 4 in severe group were not significantly higher than them in moderate group (p>0.05).
4. There were some side effects of etretinate such as cheilitis, dry mouth, and side effects of modified Ingram therapy such as erythema, pruritus. But there was no discontinuation of therapy due to side effect.
5. In 22 patients who were followed up at least one year, the mean remission time was 14.9 months in moderate group and 6.9 months in severe group.
@ES Conclusion :
@EN Our study suggests that retinoid-modified Ingram regimen is effective and tolerable in the treatment of psoriasis, especially in severe group.
(Kor J Dermatol 1996;34(1) : 240~247)
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